synomag®

Magnetic nanoparticles with excellent properties as tracer for Magnetic Particle Imaging and hyperthermia applications

  • contain a maghemite core with „nanoflower“ structure
  • are available with COOH surface and hydrodynamic particle diameters of 30 nm and 50 nm (synomag®),
  • are supplied with a dextran surface with hydrodynamic particle diameters of 50 nm and 70 nm (synomag®-D),
  • are available with a starch surface and a hydrodynamic particle diameter of 100 nm (synomag®-S),
  • synomag®-D and synomag®-S are designed with the surface groups OH (plain), COOH, PEG-COOH, NH2 and PEG-NH2 for the covalent binding of proteins, antibodies and other molecules,
  • are available with PEG-OMe (25 kDa) surface for prolonged circulation time in blood,
  • are available with covalently bound streptavidin for the binding of biotinylated molecules or with biotin on the surface for conjugation of streptavidin derivates,
  • cannot be separated with a conventional permanent magnet but in a high gradient magnetic field.

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References
  • Bender, P., Fock, J., Frandsen, C., Hansen, M.F., Balceris, C., Ludwig, F., Posth, O., Wetterskog, E., Bogart, L.K., Southern, P., Szczerba, W., Zeng, L., Witte, K., Gruettner, C., Westphal, F., Honecker, D., González-Alonso, D., Fernández Barquín, L., and Johansson, C., Relating Magnetic Properties and High Hyperthermia Performance of Iron Oxide Nanoflowers, The Journal of Physical Chemistry C, 2017, doi: 10.1021/acs.jpcc.7b11255;
  • Gavilán, H., Kowalski, A., Heinke, D., Sugunan, A., Sommertune, J., Varón, M., Bogart, L.K., Posth, O., Zeng, L., González-Alonso, D., Balceris, C., Fock, J., Wetterskog, E., Frandsen, C., Gehrke, N., Grüttner, C., Fornara, A., Ludwig, F., Veintemillas- Verdaguer, S., Johansson, C., and Puerto Morales, M., Colloidal Flower-Shaped Iron Oxide Nanoparticles: Synthesis Strategies and Coatings, Particle & Particle Systems Characterization, 2017, 1700094 doi: 10.1002/ppsc.201700094;
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