micromod
Services
We provide several services concerning development, modification and characterization of micro- and nanoparticles on basis of our existing product lines, technologies and analytical methods.
Our expertise
Focus of our products and services
Polymer particles
with a uniform and defined size in the nano and micrometer range, available in aqueous suspension with selectable particle concentration.
Monodisperse polymer particles
which, due to their magnetizability, can be influenced and steered in their direction of movement by external magnetic fields.
Development & Manufacturing
of different coatings for polymer and other particles with functional groups, functionalized sequences and partial structures.
magnetizable nanoparticles
for customer-specific application in life sciences
Application adaptation
Development, production and application adaptation of magnetic nanoparticles (BNF), which contain thermally blocked iron oxide crystallites and have biochemical or biomedical functional properties.
Custom particles
Development and production of customized particle types
Wir übernehmen die Entwicklung und kontinuierliche Produktion von kundenspezifischen Partikeltypen auf der Basis des bestehenden Sortiments und der vorhandenen Technologien.
Kundenspezifische Merkmale beziehen sich auf die Partikelstruktur (Matrixmodifikation), deren Funktionalität (funktionelle Gruppen, Farbstoffe, Antikörper oder andere Biomarker) und ihre Formulierung (Konzentration, Puffer, Stabilisatoren und andere Additive).
Finale Produktspezifikationen und Produktionsmodalitäten werden üblicherweise in bilateralen Lieferverträgen geregelt.
Custom production
Customized filling of products
We take care of customer-specific packaging of our products with regard to filling volume, concentration, dispersion medium and outer packaging, if these are to be used as system components, for example.
We can produce your particles under controlled hygienic conditions.
The requirements and specifications for particle production under controlled hygienic conditions (room hygiene, clothing regulations) are regulated in our company in a hygiene concept.
Application-related formulations of our particles can be made in consultation with the customer.
Contract analytics
Particle analysis
We offer you different types of particle analysis.
We perform particle size measurements for a price of 50 – 70 € per sample. Depending on the particle diameter we use the following measurement methods: Depending on the particle diameter we use the following measurement methods:
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Size measurement of particles with diameters below 2 µm
The size distribution of nanoparticles with diameters smaller than 2000 nm is measured using photon correlation spectroscopy with the Zetasizer NanoZS90, MALVERN Instruments Ltd., UK according to DIN ISO 13321.
Photon correlation spectroscopy (PCS) is a dynamic light scattering method used to determine the mean hydrodynamic particle diameter and the polydispersity index as a measure of the width of the distribution 1.The calibration of the PCS measurement occurs according to the DIN EN ISO 13485 with Nanosphere® size standards (Duke Scientific Corp., USA).
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Size measurement of particles with diameters of 2 µm to 30 µm
The size of microparticles in the size range from 2 to 30 µm is measured with a flexible multi-channel particle analyzer (Multisizer III, COULTER® Electronics Ltd., U.K.) 2. 2. The size measurement is calibrated according to our DIN EN ISO 13485 regulations using particles -Size standards from Duke Scientific Corp., USA.
1 http://www.malvern.com/common/downloads/campaign/MRK656-01.pdf
2 https://www.beckmancoulter.com/wsrportal/wsrportal.portal
We perform zetapotential measurements of particles with diameters smaller than < 20 µm on request.
The price for determining the pH-dependant zetapotential within the pH range of 3 to 9 is 85 € per sample.
The price for a single zetapotential measurement in an electrolyte of your choice is 50 € per sample.
The Zetasizer NanoZS90 (MALVERN Instruments Ltd., UK) is used to measure the zetapotential of particles with diameters smaller than 20 µm. The combination of the zetasizer with an autotitrator also allows the zetapotential measurement at different pH values.
Determination of the zetapotential of nano- and microparticles is achieved using Laser-Doppler-Anemometry, which follows particle movement in an electrical field [1].
The verification of our zetapotential occurs according to the DIN EN ISO 13485 with the zetapotential transfer standards from MALVERN Instruments Ltd., UK.
1 For further information on the theory of zetapotential measurements see http://www.malvern.de/LabGer/technology/zeta_potential/zeta_potential_LDE.htm
Biocoating
Coupling of antibodies, peptides, oligonucleotides and other molecules
We provide the conjugation of biomolecules or other application-relevant target molecules on a variety of our particles.
Thereby we recommend the binding of thiolated antibodies, peptides or other proteins on the surface of maleimide-functionalized particles [1]-[4].
Oligonucleotides with a terminal amino group can be bound to carboxylated particles via carbodiimide chemistry.
Other conjugation strategies, e.g. Click chemistry variants, can be applied on request.
- Grüttner C., Müller K., Teller J., Westphal F., Foreman A. R., Ivkov R., Synthesis and antibody conjugation of magnetic nanoparticles with improved specific power absorption rates for alternating magnetic field cancer therapy. J. Magn. Magn. Mat., 2007, 311:181-186.
- Natarajan A., Xiong C.-Y., Grüttner C., DeNardo G. L., DeNardo S. J., Development of multivalent radioimmunonanoparticles for cancer imaging and therapy. Cancer Biother. Radiopharm., 2008. 23:82-91.
- Natarajan A., Xiong C.-Y., Grüttner C., DeNardo G. L. , DeNardo S. J. Development of 111-In-DOTA-di-scFv-NP (Bioprobes) for cancer therapy. J. Nucl. Med., 2008. 48 (Suppl. 2):71 P.
- Rimkus G.. Design und Validierung einer mVCAM-1-spezifischen magneto-optischen Nanopartikelsonde für die Molekular Bildgebung. PhD Thesis, Biologisch-Pharmazeutische Fakultät, Jena: Friedrich-Schiller-Universität, 2011.
Do you need advice on our services or support
for your project? We are here for you!
We would be happy to advise you by phone or you can send us your request via the contact form!
- +49 381 79 99 70 00
- info@micromod.de
