micromod
Services
We provide several services concerning development, modification and characterization of micro- and nanoparticles on basis of our existing product lines, technologies and analytical methods.
Our expertise
Focus of our products and services
Polymer particles
with a uniform and defined size in the nano and micrometer range, available in aqueous suspension with selectable particle concentration.
Monodisperse polymer particles
which, due to their magnetizability, can be influenced and steered in their direction of movement by external magnetic fields.
Development & Manufacturing
of different coatings for polymer and other particles with functional groups, functionalized sequences and partial structures.
magnetizable nanoparticles
for customer-specific application in life sciences
Application adaptation
Development, production and application adaptation of magnetic nanoparticles (BNF), which contain thermally blocked iron oxide crystallites and have biochemical or biomedical functional properties.
Custom particles
Development and production of customized particle types
We perform the development and continuous production of customer-specific particle types on the basis of our existing product line and technologies.
Customer-specific product properties relate to the particle structure (matrix modification), the functionality (functional groups, dyes, antibodies or other biomarkers) and the formulation (concentration, buffer, stabilizers and other additives).
Final product specifications and production modalities are typically regulated in bilateral supply agreements.
Custom production
Customized filling of products
We take care of customer-specific packaging of our products with regard to filling volume, concentration, dispersion medium and outer packaging, if these are to be used as system components, for example.
We can produce your particles under controlled hygienic conditions.
The requirements and commitments for particle production under controlled hygienic conditions (hygiene of the environment, garment guidelines) are regulated by our hygiene concept.
Application-related formulations of our particles can be made in consultation with the customer.
Modification
particle processing & - treatment
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We take over the surface modification of particles provided by customers based on existing technologies.
Depending on the particle structure, the surface modification can be carried out in one or more stages by reactive polymerization or co-condensation.
This service can be used for both organic polymer particles and inorganic (mineral) particle types.
In principle, the drying of our particles can be performed for an additional charge of 30 € (45 USD). However, after drying the product specifications detailed in the technical data sheets can not be guaranteed.
The drying process irreversibly influences the particle structure of nanomag® and BNF particles. If silica particles with diameters between 50 nm and 300 nm are to be used as powder, we would recommend a prior trimethylsilyl coating.
We would be happy to advise you on the drying of our various particle types.
Contract analytics
Particle analysis
We offer you different types of particle analysis.
We perform particle size measurements for a price of 40 € (55 USD) per sample. Depending on the particle diameter we use the following measurement methods:
Size measurement of particles with diameters below 2 µm
The size of nanoparticles with diameters smaller than 2 µm is measured by photon correlation spectroscopy (PCS) according to DIN ISO 13321 with a Zetasizer NanoZS90, MALVERN Instruments Ltd., UK.
Photon correlation spectroscopy uses dynamic light scattering to estimate the mean hydrodynamic particle diameter and the polydispersity index as measure for the degree of the size distribution [1].The calibration of the PCS measurement occurs according to the DIN EN ISO 13485 with Nanosphere® size standards (Duke Scientific Corp., USA).
Size measurement of particles with diameters of 2 µm to 30 µm
The size of microparticles in the size range from 2 to 30 µm is measured with a flexible multi-channel particle analyzer (Multisizer III, COULTER® Electronics Ltd., U.K.) 2. The size measurement is calibrated according to our DIN EN ISO 13485 regulations using particles -Size standards from Duke Scientific Corp., USA.
1 http://www.malvern.com/common/downloads/campaign/MRK656-01.pdf
2 https://www.beckmancoulter.com/wsrportal/wsrportal.portal
We perform zetapotential measurements of particles with diameters smaller than < 20 µm on request.
The price for determining the pH-dependant zetapotential within the pH range of 3 to 9 is 70 € (95 USD) per sample.
The price for a single zetapotential measurement in an electrolyte of your choice is 40 € (55 USD) per sample.
The Zetasizer NanoZS90 (MALVERN Instruments Ltd., UK) is used to measure the zetapotential of particles with diameters smaller than 20 µm. The combination of the zetasizer with an autotitrator also allows the zetapotential measurement at different pH values.
Determination of the zetapotential of nano- and microparticles is achieved using Laser-Doppler-Anemometry, which follows particle movement in an electrical field [1].
The verification of our zetapotential occurs according to the DIN EN ISO 13485 with the zetapotential transfer standards from MALVERN Instruments Ltd., UK.
1 For further information on the theory of zetapotential measurements see http://www.malvern.de/LabGer/technology/zeta_potential/zeta_potential_LDE.htm
Biocoating
Coupling of antibodies, peptides, oligonucleotides and other molecules
We provide the conjugation of biomolecules or other application-relevant target molecules on a variety of our particles.
Thereby we recommend the binding of thiolated antibodies, peptides or other proteins on the surface of maleimide-functionalized particles [1]-[4].
Oligonucleotides with a terminal amino group can be bound to carboxylated particles via carbodiimide chemistry.
Other conjugation strategies, e.g. Click chemistry variants, can be applied on request.
- Grüttner C., Müller K., Teller J., Westphal F., Foreman A. R., Ivkov R., Synthesis and antibody conjugation of magnetic nanoparticles with improved specific power absorption rates for alternating magnetic field cancer therapy. J. Magn. Magn. Mat., 2007, 311:181-186.
- Natarajan A., Xiong C.-Y., Grüttner C., DeNardo G. L., DeNardo S. J., Development of multivalent radioimmunonanoparticles for cancer imaging and therapy. Cancer Biother. Radiopharm., 2008. 23:82-91.
- Natarajan A., Xiong C.-Y., Grüttner C., DeNardo G. L. , DeNardo S. J. Development of 111-In-DOTA-di-scFv-NP (Bioprobes) for cancer therapy. J. Nucl. Med., 2008. 48 (Suppl. 2):71 P.
- Rimkus G.. Design und Validierung einer mVCAM-1-spezifischen magneto-optischen Nanopartikelsonde für die Molekular Bildgebung. PhD Thesis, Biologisch-Pharmazeutische Fakultät, Jena: Friedrich-Schiller-Universität, 2011.
Do you need advice on our services or support
for your project? We are here for you!
We would be happy to advise you by phone or you can send us your request via the contact form!
- +49 381 79 99 70 00
- info@micromod.de
