micromod
Services
We provide several services concerning development, modification and characterization of micro- and nanoparticles on basis of our existing product lines, technologies and analytical methods.
Our expertise
Focus of our products and services
Polymer particles
with a uniform and defined size in the nano and micrometer range, available in aqueous suspension with selectable particle concentration.
Monodisperse polymer particles
which, due to their magnetizability, can be influenced and steered in their direction of movement by external magnetic fields.
Development & Manufacturing
of different coatings for polymer and other particles with functional groups, functionalized sequences and partial structures.
magnetizable nanoparticles
for customer-specific application in life sciences
Application adaptation
Development, production and application adaptation of magnetic nanoparticles (BNF), which contain thermally blocked iron oxide crystallites and have biochemical or biomedical functional properties.
Custom production
Development and production of customized particle types
We handle the development and continuous production of custom particle types based on our existing product range and technologies.
Customized features relate to the particle structure (matrix modification), their functionality (functional groups, dyes, antibodies, or other biomarkers), and their formulation (concentration, buffers, stabilizers, and other additives).
Final product specifications and production terms are typically governed by bilateral supply agreements.
Customized filling of products
We take care of customer-specific packaging of our products with regard to filling volume, concentration, dispersion medium and outer packaging, if these are to be used as system components, for example.
We can produce your particles under controlled hygienic conditions.
The requirements and specifications for particle production under controlled hygienic conditions (room hygiene, clothing regulations) are regulated in our company in a hygiene concept.
Application-related formulations of our particles can be made in consultation with the customer.
Contract analytics
We offer you different types of particle analysis.
We offer particle size measurements at a price of 55–75 EUR per sample. Depending on the particle diameter we use the following measurement methods:
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Size measurement of particles with diameters below 2 µm
The size distribution of nanoparticles with diameters smaller than 2000 nm is measured using photon correlation spectroscopy with the Zetasizer NanoZS90 or Zetasizer Ultra, MALVERN Instruments Ltd., UK, in accordance with DIN ISO 13321.
Photon correlation spectroscopy uses dynamic light scattering to estimate the mean hydrodynamic particle diameter and the polydispersity index as measure for the degree of the size distribution [1].
The calibration of the PCS measurement occurs according to the DIN EN ISO 13485 with Nanosphere® size standards (Duke Scientific Corp., USA). -
Size determination of particles with diameters from 2 µm to 30 µm
The size of microparticles in the size range from 2 to 30 µm is measured using a flexible multi-channel particle analyzer (Multisizer III, COULTER® Electronics Ltd., U.K.) 2. Size measurement is calibrated in accordance with our DIN EN ISO 13485 regulations using particle size standards from Duke Scientific Corp., USA.
1 http://www.malvern.com/common/downloads/campaign/MRK656-01.pdf
2 https://www.beckmancoulter.com/wsrportal/wsrportal.portal
We measure the zeta potential of particles with a diameter < 20 µm for you.
The price for determining the zeta potential as a function of pH in the pH range from 3 to 9 is EUR 90 per particle sample.
The price for determining the zeta potential in an electrolyte of your choice is EUR 55 per particle sample.
The Zetasizer Ultra (MALVERN Instruments Ltd., UK) is used to measure the zeta potential of particles in the size range from 15 nm to 20 µm. By coupling the Zetasizer with an autotitrator, it is possible to measure the zeta potential of particles at different pH values.
To determine the zeta potential of nano- and microparticles, laser Doppler anemometry is used to track the movement of particles in an electric field and determine the zeta potential from this 1.
The zeta potential measurement is verified in accordance with DIN EN ISO 13485 according to specified work instructions using the zeta potential transfer standard from MALVERN Instruments Ltd., UK.
An additional flat fee of EUR 100 per order will be charged for documenting the product-related analysis of products provided.
1 For further information on the theory of zetapotential measurements see http://www.malvern.de/LabGer/technology/zeta_potential/zeta_potential_LDE.htm
Biocoating
Coupling of antibodies, peptides, oligonucleotides and other molecules
We offer the conjugation of biomolecules or other application-specific target molecules to a wide variety of our particles.
For binding antibodies and peptides, we prefer to conjugate thiol-containing biomolecules to the surface of maleimide-modified particles.
Oligonucleotides with a terminal amino group can be conjugated to carboxylated particles using carbodiimide chemistry.
Other conjugation strategies, such as variants of click chemistry, can be employed upon request.
Do you need advice on our services or support
for your project? We are here for you!
We would be happy to advise you by phone or you can send us your request via the contact form!
- +49 381 79 99 70 00
- info@micromod.de
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