sicastar®-M

Magnetic silica particles (sicastar®-M)

  • are available with mean diameters of 350 nm or 1.5 µm
  • are produced by hydrolysis of orthosilicates in the presence of magnetite,
  • have a hydrophilic surface with terminal Si-OH-bonds (plain),
  • have monomodal size distributions,
  • can easily be separated with conventional permanent magnets,
  • are extremely stable in organic solvents and at high temperatures,
  • are designed with the surface functionalities NH2, COOH, N-hydroxysuccinimide (NHS) and epoxy for the covalent binding of proteins, antibodies or other molecules,
  • can be offered with the nickel-(II)-complex of nitrilotriacetic acid (Ni-NTA) for the binding of histidine labeled proteins,
  • are available with a hydrophobic octadecyl (C18) surface.

 

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References
  • C. Grüttner, K. Müller and J. Teller, A rapid assay to measure the shielding of iron oxide cores by the particle shell, IEEE Trans. Magn., 2013, 49(1), 177–181;
  • A. Roque, S. Bispo, A. Pinheiro, J. Antunes, D. Gonçalves and H. Ferreira, Antibody immobilization on magnetic particles, Journal of Molecular Recognition, 2009, 22(2), 77–82;
  • Weber, E., Günther, D., Zellmer, S., Goldberg, M., Bergmann, C., Herrmann, C., Huske, A., and Müller, A., Immunomagnetic separation of specific target cells, 2005, US Patent 20050003559, 1-9;
  • A. Mandil, L. Idrissi and A. Amine, Stripping voltammetric determination of mercury (II) and lead (II) using screen-printed electrodes modified with gold films, and metal ion preconcentration with thiol-modified magnetic particles, Microchimica Acta, 2010, 170(3-4), 299–305;
  • S. Hughes, S. C. McBain, J. Dobson and A. J. El Haj, Selective activation of mechanosensitive ion channels using magnetic particles, J. R. Soc. Interface, 2008, 5(855–863;
  • R. Palankar, U. Binsker, B. Haracska, J. Wesche, A. Greinacher and S. Hammerschmidt, Interaction between the Staphylococcus aureus extracellular adherence protein Eap and its subdomains with platelets, International Journal of Medical Microbiology, 2018, 308(6), 683–691;
  • P. D. Skottrup, M. Fought Hansen, J. Moresco Lange, M. Deryabina, W. E. Svendsen, M. Havsteen Jakobsen and M. Dufva, Superparamagnetic bead interactions with functionalized surfaces characterized by an immunomicroarray, Acta Biomater, 2010, 6(3936–3946;
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