sicastar®-M

Magnetic silica particles (sicastar®-M)

  • are available with mean diameters of 350 nm or 1.5 µm
  • are produced by hydrolysis of orthosilicates in the presence of magnetite,
  • have a hydrophilic surface with terminal Si-OH-bonds (plain),
  • have monomodal size distributions,
  • can easily be separated with conventional permanent magnets,
  • are extremely stable in organic solvents and at high temperatures,
  • are designed with the surface functionalities NH2, COOH, N-hydroxysuccinimide (NHS) and epoxy for the covalent binding of proteins, antibodies or other molecules,
  • can be offered with the nickel-(II)-complex of nitrilotriacetic acid (Ni-NTA) for the binding of histidine labeled proteins,
  • are available with a hydrophobic octadecyl (C18) surface.

 

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References
  • Grüttner, C., Müller, K., and Teller, J., A rapid assay to measure the shielding of iron oxide cores by the particle shell, IEEE Trans Magn, 2013, 49(1), 177-81;
  • Diller, S., Grassl, r., Miller, S., Robl, I., Schultz, M., and Zander, T., Method for unspecific enrichment of bacterial cells, US 0019827, 2005;
  • Weber, E., Günther, D., Zellmer, S., Goldberg, M., Bergmann, C., Herrmann, C., Huske, A., and Müller, A., Immunomagnetic separation of specific target cells, 2005, US Patent 20050003559, 1-9;
  • Mandil, A., Idrissi, L., and Amine, A., Stripping voltammetric determination of mercury (II) and lead (II) using screen-printed electrodes modified with gold films, and metal ion preconcentration with thiol-modified magnetic particles, Microchimica Acta, 2010, 170(3-4), 299-305;
  • Hughes, S., McBain, S.C., Dobson, J., and El Haj, A.J., Selective activation of mechanosensitive ion channels using magnetic particles, J R Soc Interface, 2008, 5, 855-63;
  • Skottrup, P.D., Fought Hansen, M., Moresco Lange, J., Deryabina, M., Svendsen, W.E., Havsteen Jakobsen, M., and Dufva, M., Superparamagnetic bead interactions with functionalized surfaces characterized by an immunomicroarray, Acta Biomater, 2010, 6, 3936-46;
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