micromod

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We provide several services concerning development, modification and characterization of micro- and nanoparticles on basis of our existing product lines, technologies and analytical methods.

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micromod Partikeltechnologie

Schillingallee 68 | D-18057 Rostock

We would be happy to advise you by phone or you can send us your request via the contact form!

FAQ

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Here you might find answers for some typical questions. For any further questions please contact us.

Orders may be placed via website (www.micromod.de), e-mail (info@micromod.de) or fax (+49 381 79997070). Please have shipping and billing information available. European customers have to provide their VAT number.

Orders may be placed using a purchase order or credit card. We accept Visa and MasterCard.

All shipments will be arranged with United Parcel Service (UPS). Freight and insurance charges are prepaid and added to the invoice (DAP destination). The standard shipment fee is 35 EUR to Europe, 60 USD to USA, 70 EUR (100 USD) to Japan and other countries. Some countries imposes Entry customs clearance / Entry Taxation fees for import, these are not included.
If you wish to use an own courier account, please specify the courier and account number at the time of ordering.

Customers from Asian countries can place their orders via local traders:

JAPAN
Corefront Corporation (www.corefront.com)
Funakoshi Corporation (www.funakoshi.co.jp)
Nacalai Tesque Inc. (www.nacalai.com)

CHINA
Hannotech Co. Ltd. (www.hannotech.com.cn)
Shanghai Biochemical Co. Ltd. (www.shbcbio.com)

TAIWAN
KYS Technology Co., Ltd. (www.kyst.com.tw.com)

SOUTH KOREA
JYSCO Ltd. (www.jysco.com)

SINGAPORE
Scientific Procurement (S) Pte Ltd. (www.scientificprocurement.com)

You can download a pdf-Version of our print catalog from the print catalog link on our website.

All particle diameters that are given in our product descriptions and technical data sheets are nominal values which may deviate from the measured mean particle diameter. The size of particles with diameter < < 2 µm is measured by Dynamic Light Scattering (DLS) with the Zetasizer Nano ZS 90 (Malvern Instr. Ltd.). DLS is also known as Photon Correlation Spectroscopy (PCS). The size of particles ≥ 2 µm is measured with the Coulter® Multisizer III. The specification for the particle diameter and the size distribution of each particle type is available on request.

Translated by www.DeepL.com/Translator (free version)

The size of particles with diameter ≥ 2 µm is measured with the COULTER® Multisizer II. This is a multichannel particle size analyzer, which employs the electrical impedance method to provide a particle size distribution analysis. The method is based on the change of the impedance, when a particle passes the measurement zone. This change is proportional to the particle volume.

The coefficient of variation (CV) typically refers to the size variation of a bead population. The CV relates the measure of dispersion to the average about which it is measured in percentage. The CV is obtained by dividing the standard deviation by the mean particle diameter, i.e.: % CV = 100 % x Standard deviation / Mean diameter.
Our micromer® particles with diameters between 2 and 10 µm have CV values ≤ 5%.

In general the size of particles with diameters < < 2 µm is measured by Dynamic Light Scattering (DLS) with the Zetasizer Nano ZS 90 (Malvern Instr. Ltd.). DLS is also known as Photon Correlation Spectroscopy (PCS).
The Zetasizer determines the size by first measuring the Brownian motion of the particles in a sample using Dynamic Light Scattering (DLS) and then interpreting a size from this using established theories.

There are four different types of data analysis of the PCS measurement:
– the cumulants analysis
– the multi exponential analysis,
– the CONTIN analysis and
– the non negative least squares analysis.

The Z-average Size is the most important and stable number produced by the technique. This is the size to use if a number is required for quality control purposes.
The Z-average Size is obtained by the cumulants analysis. This analysis gives only two values, a mean value for the size and a width parameter known as Polydispersity Index (PDI). This mean size is an intensity mean and directly calculated from the signal intensity.
According to our experiences we use different types of analysis for the evaluation of our nanoparticles. Especially the different scattering properties of fluorescent or magnetic nanoparticles require on optimal adjustment of the analytical methods.

The size distribution of our nanoparticles is measured by photon correlation spectroscopy (PCS). The quality of size distribution is given by the polydispersity index (PDI). This value is calculated as deviation between the measured autocorrelation function and the mathematically adapted correlation function. This value is below 0.2 for nanoparticles with a small size distribution and between 0.2 and 0.5 for broad size distributions. PDI values higher than 0.5 show that the measurement can not be analyzed.

We measure the Zeta Potential of our particles with the Zetasizer Nano ZS 90 (Malvern Instr. Ltd.). The Zeta Potential is measured using a combination of the measurement techniques: Electrophoresis and Laser Doppler Velocimetry, sometimes called Laser Doppler Electrophoresis. This method measures how fast a particle moves in a liquid when an electrical field is applied – i.e. its velocity.

We recommend the SEPMAG Q1L (www.sepmag.eu) for volumes up to 1L. For example, our nanomag-D, 500 nm particles (V = 600 ml, c = 10 mg/ml, product code: 09-00-502) were separated with the SEPMAG Q1L within ~ 30 min.

The amino functionalization of silica particles is performed by polycondensation of the Si-OH groups on the surface of plain silica particles with 3-(aminopropyl)triethoxysilane. Beside the NH2 groups there are numerous acidic Si-OH groups on the particle surface available that are responsible for the overall negative zeta potential of the amino-functionalized silica particles. The comparison of the zeta potential-pH functions of plain and amino functionalized silica particles with a diameter of 1 µm demonstrates the shift of the zeta potential of plain silica particles into positive direction for amino functionalized silica particles. The amino functionalized silica particles have a positive zeta potential at pH < 4 and a negative zeta potential at pH > 4.

for download
Technotes
The 100-Serie of Technotes

The 100-Serie of Technotes is concerned with separation and purification of micro- and nanoparticles.

Technote 100

Centrifugation Parameters for Particle Washing

Technote 101

Separation of Magnetic Particles

Technote 102

Purification of Nanoparticles by Size Exclusion Chromatography (SEC)

Technote 103

Purification of Nanoparticles by Dialysis

The 200-Serie of Technotes

The 200-Serie describes further surface modification of micro- and nanoparticles and their conjugation with biomolecules.

Technote 200

Binding of Biomolecules on the Surface of Carboxylated Particles by Carbodiimide Chemistry

Technote 201

Conjugation of Biomolecules to the Surface of Maleimide Functionalized Particles

Technote 202

Maleimide Functionalization of Aminated Particles

Technote 203

Poly-D-lysine Coating of Magnetic Nanoparticles for Cell Uptake

The 300-Serie of Technotes

The 300-Serie describes analytical methods for the characterisation of micro- and nanoparticles and their conjugates with biomolecules.

Technote 301

Determination of the amount of covalently bound proteins on the surface of magnetic nanoparticles

Everything at once
Downloads

You can download our research highlights, product group catalogs and brochures here as a pdf version. On request we deliver our brochures also as paper version.

Research highlights

synomag®-D

our new Magnetic Nanoparticle

perimag®

our new Magnetic Nanoparticle Type

Product catalogs
Brochures

Image brochure

micromod Partikeltechnologie GmbH

Application brochure

magnetic micro- and nanoparticles