nanomag®-silica

Silica-fortified magnetic dextran nanoparticles (nanomag®-silica)

  • are prepared via the core-shell method with a core of magnetite and a dextran shell with a simultaneous cross-linking of the dextran strands by silica nanostructures,
  • have a diameter of 250 nm and a magnetite content of 75-80%,
  • can easily be separated with a conventional permanent magnet,
  • are designed with the surface functionalities OH (plain), NH2 and COOH for the covalent binding of proteins, antibodies or other molecules,
  • are available with the hydrophobic octadecyl (C18) surface especially for nucleic acid separation.


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References
  • M. Bu, T. B. Christensen, K. Smistrup, A. Wolff and M. F. Hansen, Characterization of a microfluidic magnetic bead separator for high-throughput applications, Sensors and Actuators A: Physical, 2008, 145(430–436;
  • C. Grüttner and J. Teller, New types of silica-fortified magnetic nanoparticles as tools for molecular biology applications, Journal of Magnetism and Magnetic Materials, 1999, 194(1), 8–15;
  • S. J. Kuhn, S. K. Finch, D. E. Hallahan and T. D. Giorgio, Proteolytic surface functionalization enhances in vitro magnetic nanoparticle mobility through extracellular matrix, Nano letters, 2006, 6(2), 306–312;
  • S. J. Kuhn, S. K. Finch, D. E. Hallahan and T. D. Giorgio, Facile production of multivalent enzyme-nanoparticle conjugates, Journal of Magnetism and Magnetic Materials, 2007, 311(1), 68–72;
  • S. J. Kuhn, D. E. Hallahan and T. D. Giorgio, Characterization of superparamagnetic nanoparticle interactions with extracellular matrix in an in vitro system, Ann. Biomed. Eng., 2006, 34(1), 51–58;
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