Silica-fortified magnetic dextran nanoparticles (nanomag®-silica)

  • are prepared via the core-shell method with a core of magnetite and a dextran shell with a simultaneous cross-linking of the dextran strands by silica nanostructures,
  • have a diameter of 250 nm and a magnetite content of 75-80%,
  • can easily be separated with a conventional permanent magnet,
  • are designed with the surface functionalities OH (plain), NH2 and COOH for the covalent binding of proteins, antibodies or other molecules,
  • are available with the hydrophobic octadecyl (C18) surface especially for nucleic acid separation.

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  • Bu, M., Christensen, T.B., Smistrup, K., Wolff, A., and Hansen, M.F., Characterization of a microfluidic magnetic bead separator for high-throughput applications, Sensors and Actuators A: Physical, 2008, 145, 430-6;
  • Grüttner, C., and Teller, J., New types of silica-fortified magnetic nanoparticles as tools for molecular biology applications, Journal of Magnetism and Magnetic Materials, 1999, 194(1), 8-15;
  • Kuhn, S.J., Development and characterization of functionalized superparamagnetic nanoparticles for interstitial applications, PhD thesis, 2005;
  • Kuhn, S.J., Finch, S.K., Hallahan, D.E., and Giorgio, T.D., Proteolytic surface functionalization enhances in vitro magnetic nanoparticle mobility through extracellular matrix, Nano letters, 2006, 6(2), 306-12;
  • Kuhn, S.J., Finch, S.K., Hallahan, D.E., and Giorgio, T.D., Facile production of multivalent enzyme-nanoparticle conjugates, Journal of Magnetism and Magnetic Materials, 2007, 311(1), 68-72;
  • Kuhn, S.J., Hallahan, D.E., and Giorgio, T.D., Characterization of superparamagnetic nanoparticle interactions with extracellular matrix in an in vitro system, Ann Biomed Eng, 2006, 34(1), 51-8;
  • Lawton, R., Soluble analyte detection and amplifiction, US 0048500, 2003;
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