Dextran based magnetic nanoparticles (perimag®)

  • exhibit excellent properties as contrast agents for Magnetic Resonance Imaging (MRI) and Magnetic Particle Imaging (MPI) (Eberbeck et al. 2013, Konkle et al. 2015 and Zheng et al. 2016),
  • are suitable for homing and tracking of stem cells in regenerative medicine as well as for hyperthermia applications (Kilian et al. 2016),
  • are prepared by precipitation of iron oxide in the presence of dextran,
  • are available with a particle diameter of 130 nm,
  • cannot be separated with a conventional permanent magnet but in a high gradient magnetic field,
  • are designed with the surface functionalities OH (plain), NH2 and COOH for the covalent binding of proteins, antibodies or other molecules (Drews et al. 2013),
  • are available with covalently bound streptavidin for the binding of biotinylated molecules,
  • can be manufactured with higher iron concentration upon request.

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  • Abdollah, M.R.A., Carter, T.J., Jones, C., Kalber, T.L., Rajkumar, V., Tolner, B., Gruettner, C., Zaw-Thin, M., Baguña Torres, J., Ellis, M., Robson, M., Pedley, R.B., Mulholland, P., T. M. de Rosales, R., and Chester, K.A., Fucoidan Prolongs the Circulation Time of Dextran-Coated Iron Oxide Nanoparticles, ACS Nano, 2018, doi: 10.1021/acsnano.7b06734;
  • Eberbeck, D., Dennis, C.L., Huls, N.F., Krycka, K.L., Gruttner, C., and Westphal, F., Multicore magnetic nanoparticles for magnetic particle imaging, IEEE TRANSACTIONS ON MAGNETICS, 2013, 49(1), 269-74;
  • Konkle, J.J., Goodwill, P.W., Hensley, D.W., Orendorff, R.D., Lustig, M., and Conolly, S.M., A Convex Formulation for Magnetic Particle Imaging X-Space Reconstruction, PloS one, 2015, 10(10), e0140137;
  • Zheng, B., Marc, P., Yu, E., Gunel, B., Lu, K., Vazin, T., Schaffer, D.V., Goodwill, P.W., and Conolly, S.M., Quantitative Magnetic Particle Imaging Monitors the Transplantation, Biodistribution, and Clearance of Stem Cells In Vivo, Theranostics, 2016, 6(3), 291-301;
  • Drews, L.B., Croft, L.R., Kosuge, H., Saritas, E.U., Goodwill, P.W., McConnell, M.V., Conolly, S.M., and Tirrell, M.V., Imaging atherosclerotic plaques in vivo using peptide-functionalized iron oxide nanoparticles, Magnetic Particle Imaging (IWMPI), 2013 International Workshop on, 2013, 1-;
  • Kilian, T., Fidler, F., Kasten, A., Nietzer, S., Landgraf, V., Weiß, K., Walles, H., Westphal, F., Hackenberg, S., Grüttner, C., and Steinke, M., Stem cell labeling with iron oxide nanoparticles: impact of 3D culture on cell labeling maintenance, Nanomedicine, 2016, 11(15), 1957-70;
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