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Magnetic poly(ethylene imine) (PEI-M) particles are prepared via the core-shell method with a core of magnetite and a poly(ethylene imine) shell. They have a diameter of 150 nm and a magnetite content of 75-80%. The magnetic PEI particles can easily be separated with a conventional permanent magnet and are interesting tools for magnetic driven transfection of cells (McBain et al., 2007).