nanomag®-D-spio

Superparamagnetic dextran nanoparticles (nanomag®-D-spio)

are available with particle diameters of 20 nm, 50 nm and 100 nm
cannot be separated with a conventional permanent magnet but in a high gradient magnetic field,
are prepared by precipitation of iron oxide in the presence of dextran,
functionalized nanomag® -D-spio consist of about 55-85% (w/w) iron oxide in a matrix of dextran (40.000 Da) in dependence on the diameter and surface modification,
differ in the size of the iron oxide domains for different diameters,
are preferably applied for detection purposes in magnetic resonance imaging or in magneto-immuno assays,
show good specific power absorption rates for hyperthermia applications for a particle diameter of 100 nm,
are designed with the surface functionalities OH (plain), NH2 and COOH for the covalent binding of proteins, antibodies or other molecules,
are available with covalently bound proteins (avidin, streptavidin, protein A, albumin) or other biomolecules (e.g. biotin),
are available with various hydrophilic surfaces (PEG 300, PEG-NH2 or PEG-COOH).