NH2

sicastar® particles are available with amino groups (NH2) on the surface in the size range from 50 nm to 20 µm. For the covalent binding of proteins, antibodies or other target molecules various conjugation methods can be applied e.g. the SPDP or maleimide functionalization for conjugation of thiolated molecules.
The particles are delivered in aqueous suspension without any surfactants.

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References
  • Hata, K., Higashisaka, K., Nagano, K., Mukai, Y., Kamada, H., Tsunoda, S.-i., Yoshioka, Y., and Tsutsumi, Y., Evaluation of silica nanoparticle binding to major human blood proteins, Nanoscale Research Letters, 2014, 9(1), 668;
  • Higashisaka, K., Kunieda, A., Iwahara, Y., Tanaka, K., Nagano, K., Mukai, Y., Kamada, H., Tsunoda, S.-i., Yoshioka, Y., and Tsutsumi, Y., Neutrophilia Due to Silica Nanoparticles Induces Release of Double-Stranded DNA, Journal of Nanomedicine & Nanotechnology, 2014, 5(5), 1;
  • Higashisaka, K., Yoshioka, Y., Yamashita, K., Morishita, Y., Pan, H., Ogura, T., Nagano, T., Kunieda, A., Nagano, K., Abe, Y., Kamada, H., Tsunoda, S.-i., Nabeshi, H., Yoshikawa, T., and Tsutsumi, Y., Hemopexin as biomarkers for analyzing the biological responses associated with exposure to silica nanoparticles, Nanoscale Res Lett, 2012, 7, 555;
  • Hinojosa, B.R., Nanoparticles engineered to bind serum albumin: Microwave assisted synthesis , characterization, and functionalization of fuorescently-labeled, acrylate- based, polymer nanoparticles, PhD thesis, 2010;
  • Morishige, T., Yoshioka, Y., Inakura, H., Tanabe, A., Yao, X., Tsunoda, S., Tsutsumi, Y., Mukai, Y., Okada, N., and Nakagawa, S., Cytotoxicity of amorphous silica particles against macrophage-like THP-1 cells depends on particle-size and surface properties, Die Pharmazie-An International Journal of Pharmaceutical Sciences, 2010, 65(8), 596-9;
  • Oehrlein, S.M., Sanchez-Perez, J.R., Jacobson, R., Flack, F.S., Kershner, R.J., and Lagally, M.G., Translation and manipulation of silicon nanomembranes using holographic optical tweezers, Nanoscale research letters, 2011, 6(1), 1-7;
  • Willmott, G., Vogel, R., Yu, S., Groenewegen, L., Roberts, G., Kozak, D., Anderson, W., and Trau, M., Use of tunable nanopore blockade rates to investigate colloidal dispersions, Journal of Physics: Condensed Matter, 2010, 22(45), 454116;