PLA particles

Poly(lactic acid) particles (PLA particles)

PLA particles consist of poly(D,L-lactic acid) with a molecular weight of 17.000 Da. They are available with diameters of 250 nm and 500 nm in small size distributions and with mean diameters of 30 µm and 100 µm in broader size distributions and a plain surface or with COOH groups on the surface.

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  • Wunderlich, G., Pinkert, J., Stintz, M., and Kotzerke, J., Labeling and biodistribution of different particle materials for radioembolization therapy with< sup> 188 Re, Applied Radiation and isotopes, 2005, 62(5), 745-50;
  • Luderer, F., Löbler, M., Rohm, H.W., Gocke, C., Kunna, K., Köck, K., Kroemer, H.K., Weitschies, W., Schmitz, K.-P., and Sternberg, K., Biodegradable Sirolimus- loaded Poly(lactide) Nanoparticles as Drug Delivery System for the Prevention of In-Stent Restenosis in Coronary Stent Application, J Biomater Appl, 2011, 25, 851-75;
  • Mima, Y., Fukumoto, S., Koyama, H., Okada, M., Tanaka, S., Shoji, T., Emoto, M., Furuzono, T., Nishizawa, Y., and Inaba, M., Enhancement of cell-based therapeutic angiogenesis using a novel type of injectable scaffolds of hydroxyapatite-polymer nanocomposite microspheres, PLoS One, 2012, 7(4), e35199;
  • Moeller, S., Kegler, R., Sternberg, K., and Mundkowski, R.G., Influence of sirolimus-loaded nanoparticles on physiological functions of native human polymorphonuclear neutrophils, Nanomedicine: Nanotechnology, Biology and Medicine, 2012, 8(8), 1293-300;
  • Weidmann, A., Kwittner, S., Beck, R., Teller, J., Jonas, L., and Nebe, B.J., Prevention of Lens Epithelial Cell Growth In Vitro Using Mibefradil- Containing PLGA Micro Particles, The Open Ophthalmology Journal, 2008, 2, 112- 8;
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