COOH
nanomag®-D particles with diameters of 130 nm, 250 nm and 500 nm are designed with carboxylic acid groups on the surface for the covalent binding of proteins, antibodies or other molecules, e.g. by carbodiimide chemistry (see technote 200). The functionalized nanomag®-D particles are supplied in water without any surfactants.
The biocompatible nanomag®-D particles were studied in hyperthermia cancer therapy (Marcos-Campos 2011). Furthermore carboxylated nanomag®-D particles were conjugated with an aptamer and investigated as nanosurgeon (Nair et al., 2010).
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References
- L. Asin, M. R. Ibarra, A. Tres and G. F. Goya, Controlled cell death by magnetic hyperthermia: effects of exposure time, field amplitude, and nanoparticle concentration, Pharm. Res., 2012, 29(1319–1327;
- J. Clarke, J. Pike, D. Bending, D. Owen, D. C. Wraith and A. J. E. Haj, Remote Force Modulation of the T‐Cell Receptor Reveals an NFAT‐Threshold for CD4+ T‐Cell Activation, European Journal of Immunology, 2025, 55(6), e51716;
- J. E. Dixon, G. Osman, G. E. Morris, H. Markides, M. Rotherham, Z. Bayoussef, A. J. El Haj, C. Denning and K. M. Shakesheff, Highly efficient delivery of functional cargoes by the synergistic effect of GAG binding motifs and cell-penetrating peptides, Proceedings of the National Academy of Sciences, 2016, 113(3), E291–E299;
- J. R. Henstock, M. Rotherham, H. Rashidi, K. M. Shakesheff and A. J. El Haj, Remotely activated mechanotransduction via magnetic nanoparticles promotes mineralization synergistically with bone morphogenetic protein 2: applications for injectable cell therapy, Stem Cells Translational Medicine, 2014, 3(11), 1363–1374;
- H. Kuramitz, Magnetic microbead-based electrochemical immunoassays, Anal Bioanal Chem, 2009, 394(61–69;
- Y.-H. Ma, S.-Y. Chen, S.-J. Tu, H.-W. Yang and H.-L. Liu, Manipulation of magnetic nanoparticle retention and hemodynamic consequences in microcirculation: assessment by laser speckle imaging, International Journal of Nanomedicine, 2012, 7(2817;
- I. Marcos-Campos, L. Asin, T. Torres, C. Marquina, A. Tres, M. Ibarra and G. F. Goya, Cell death induced by the application of alternating magnetic fields to nanoparticle-loaded dendritic cells, Nanotechnology, 2011, 22(20), 205101;
- H. Markides, J. S. McLaren, N. D. Telling, N. Alom, A. E'atelaf, R. O. Oreffo, A. Zannettino, B. E. Scammell, L. J. White and A. J. El Haj, Translation of remote control regenerative technologies for bone repair, npj Regenerative Medicine, 2018, 3(1), 9;
- G. Milano, D. Musumeci, M. Gaglione and A. Messere, An alternative strategy to synthesize PNA and DNA magnetic conjugates forming nanoparticle assembly based on PNA/DNA duplexes, Molecular BioSystems, 2010, 6(3), 553–561;
- B. G. Nair, Y. Nagaoka, H. Morimoto, Y. Yoshida, T. Maekawa and D. S. Kumar, Aptamer conjugated magnetic nanoparticles as nanosurgeons, Nanotechnology, 2010, 21(45), 455102;
- S.-M. Robatjazi, S.-A. Shojaosadati, R. Khalilzadeh and E. Farahani, Optimization of the covalent coupling and ionic adsorption of magnetic nanoparticles on Flavobacterium ATCC 27551 using the Taguchi method, Biocatalysis and Biotransformation, 2010, 304–312;
- T. Takamura, P. J. Ko, J. Sharma, R. Yukino, S. Ishizawa and A. Sandhu, Magnetic-Particle-Sensing Based Diagnostic Protocols and Applications, Sensors, 2015, 15(6), 12983–12998;
| Product ID | Name | Surface | Diameter | Concentration | Amount | Price | TDS | MSDS | Order |
|---|---|---|---|---|---|---|---|---|---|
| 09-02-132 | nanomag®-D | COOH | 130 nm | 10 mg/ml | 10 ml | 198,00 € |
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| 09-02-252 | nanomag®-D | COOH | 250 nm | 10 mg/ml | 10 ml | 186,00 € |
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| 09-02-502 | nanomag®-D | COOH | 500 nm | 10 mg/ml | 10 ml | 233,00 € |
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