NH2

BNF-Dextran or BNF-Starch particles are available with amino groups on the surface for the covalent binding of proteins, antibodies or other molecules. The matrix of the functionalized particles consists of crosslinked dextran or hydroxyethyl starch. The 100 nm particles can be separated with conventional permanent magnets, while the 80 nm particles have to be separated in high gradient magnetic fields. BNF-Starch particles can easily be filtered through 0.22 µm filters. They are supplied in water without any surfactants. The BNF particles can be provided with covalently bound antibodies on request.

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References
  • D. C. Baiu, N. S. Artz, M. R. McElreath, B. D. Menapace, D. Hernando, S. B. Reeder, C. Grüttner and M. Otto, High specificity targeting and detection of human neuroblastoma using multifunctional anti-GD2 iron-oxide nanoparticles, Nanomedicine, 2015, 10(19), 2973–2988;
  • B. Behnam Azad, S. R. Banerjee, M. Pullambhatla, S. Lacerda, C. A. Foss, Y. Wang, R. Ivkov and M. G. Pomper, Evaluation of a PSMA-targeted BNF nanoparticle construct, Nanoscale, 2015, 7(10), 4432–4442;
  • Z. Boekelheide, J. T. Miller, C. Grüttner and C. L. Dennis, The effects of intraparticle structure and interparticle interactions on the magnetic hysteresis loop of magnetic nanoparticles, Journal of Applied Physics, 2019, 126(4), 043903;
  • F. Gaffron, A. Tilch, C. Grüttner, A. Kowalski, M. Kramer and U. Teichgräber, Challenges in Tracking of Fluorochrome-Labelled Nanoparticles in Mice via Whole Body NIRF Imaging, Nanomaterials, 2020, 10(3), 596;
  • C. Grüttner, K. Müller and J. Teller, Comparison of Strain-Promoted Alkyne-Azide Cycloaddition with Established Methods for Conjugation of Biomolecules to Magnetic Nanoparticles, Magnetics, IEEE Transactions on, 2013, 49(1), 172–176;
  • P. Korangath, J. D. Barnett, A. Sharma, E. T. Henderson, J. Stewart, S.-H. Yu, S. K. Kandala, C.-T. Yang, J. S. Caserto and M. Hedayati, Nanoparticle interactions with immune cells dominate tumor retention and induce T cell–mediated tumor suppression in models of breast cancer, Science Advances, 2020, 6(13), eaay1601;
  • C. Ndong, S. Toraya-Brown, K. Kekalo, I. Baker, T. U. Gerngross, S. N. Fiering and K. E. Griswold, Antibody-mediated targeting of iron oxide nanoparticles to the folate receptor alpha increases tumor cell association in vitro and in vivo, International Journal of Nanomedicine, 2015, 10(2595;
  • E. J. Ngen, B. Behnam Azad, S. Boinapally, A. Lisok, M. Brummet, D. Jacob, M. G. Pomper and S. R. Banerjee, MRI Assessment of Prostate-Specific Membrane Antigen (PSMA) Targeting by a PSMA-Targeted Magnetic Nanoparticle: Potential for Image-Guided Therapy, Molecular pharmaceutics, 2019, 16(5), 2060–2068;
  • F. W. Østerberg, G. Rizzi, T. Zardán Gómez de la Torre, M. Strömberg, M. Strømme, P. Svedlindh and M. Hansen, Measurements of Brownian relaxation of magnetic nanobeads using planar Hall effect bridge sensors, Biosensors and Bioelectronics, 2013, 40(1), 147–152;
  • S. Schrittwieser, B. Pelaz, W. J. Parak, S. Lentijo-Mozo, K. Soulantica, J. Dieckhoff, F. Ludwig, A. Guenther, A. Tschöpe and J. Schotter, Homogeneous biosensing based on magnetic particle labels, Sensors, 2016, 16(6), 828;
  • C.-T. Yang, P. Korangath, J. Stewart, C. Hu, W. Fu, C. Grüttner, S. E. Beck, F.-H. Lin and R. Ivkov, Systemically delivered antibody-labeled magnetic iron oxide nanoparticles are less toxic than plain nanoparticles when activated by alternating magnetic fields, International Journal of Hyperthermia, 2020, 37(3), 59–75;
  • T. Zardan Gomez de la Torre, M. Strömberg, C. Russell, J. Göransson, M. Nilsson, P. Svedlindh and M. Stromme, Investigation of immobilization of functionalized magnetic nanobeads in rolling circle amplified DNA coils, J. Phys. Chem. B, 2010, 114(3707–3713;
  • Y. Zhu, K. Kekalo, C. NDong, Y. Y. Huang, F. Shubitidze, K. E. Griswold, I. Baker and J. X. Zhang, Magnetic‐Nanoparticle‐Based Immunoassays‐on‐Chip: Materials Synthesis, Surface Functionalization, and Cancer Cell Screening, Advanced Functional Materials, 2016, 26(3953–3972;