NH2

BNF-Dextran or BNF-Starch particles are available with amino groups on the surface for the covalent binding of proteins, antibodies or other molecules. The matrix of the functionalized particles consists of crosslinked dextran or hydroxyethyl starch. The 100 nm particles can be separated with conventional permanent magnets, while the 80 nm particles have to be separated in high gradient magnetic fields. BNF-Starch particles can easily be filtered through 0.22 µm filters. They are supplied in water without any surfactants. The BNF particles can be provided with covalently bound antibodies on request.

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References
  • Artemov, D., Kato, Y., and SUDATH, H., Use of oscillating gradients of high magnetic field for specific destruction of cells labeled with magnetic nanoparticles, Patent WO2014107419A1, 2014;
  • Baiu, D.C., Artz, N.S., McElreath, M.R., Menapace, B.D., Hernando, D., Reeder, S.B., Grüttner, C., and Otto, M., High specificity targeting and detection of human neuroblastoma using multifunctional anti-GD2 iron-oxide nanoparticles, Nanomedicine, 2015, 10(19), 2973-88, doi: 10.2217/nnm.15.138;
  • Behnam Azad, B., Banerjee, S.R., Pullambhatla, M., Lacerda, S., Foss, C.A., Wang, Y., Ivkov, R., and Pomper, M.G., Evaluation of a PSMA-targeted BNF nanoparticle construct, Nanoscale, 2015, 7(10), 4432-42, doi: 10.1039/C4NR06069E;
  • Grüttner, C., Müller, K., and Teller, J., Comparison of Strain-Promoted Alkyne-Azide Cycloaddition with Established Methods for Conjugation of Biomolecules to Magnetic Nanoparticles, Magnetics, IEEE Transactions on, 2013, 49(1), 172-6;
  • Østerberg, F.W., Rizzi, G., Zardán Gómez de la Torre, T., Strömberg, M., Strømme, M., Svedlindh, P., and Hansen, M., Measurements of Brownian relaxation of magnetic nanobeads using planar Hall effect bridge sensors, Biosensors and Bioelectronics, 2013, 40(1), 147-52;
  • Schrittwieser, S., Pelaz, B., Parak, W.J., Lentijo-Mozo, S., Soulantica, K., Dieckhoff, J., Ludwig, F., Guenther, A., Tschöpe, A., and Schotter, J., Homogeneous biosensing based on magnetic particle labels, Sensors, 2016, 16(6), 828;
  • Zardan Gomez de la Torre, T., Strömberg, M., Russell, C., Göransson, J., Nilsson, M., Svedlindh, P., and Stromme, M., Investigation of immobilization of functionalized magnetic nanobeads in rolling circle amplified DNA coils, J Phys Chem B, 2010, 114, 3707-13;
  • Zhu, Y., Kekalo, K., NDong, C., Huang, Y.Y., Shubitidze, F., Griswold, K.E., Baker, I., and Zhang, J.X., Magnetic‐Nanoparticle‐Based Immunoassays‐on‐Chip: Materials Synthesis, Surface Functionalization, and Cancer Cell Screening, Advanced Functional Materials, 2016;